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Home >> Antibodies >> Synaptophysin (Neuroendocrine Marker)

Synaptophysin (Neuroendocrine Marker)

Mouse Monoclonal Antibody [Clone SYP/3551]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Pancreas stained with Synaptophysin-Monospecific Mouse Monoclonal Antibody (SYP/3551).

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Formalin-fixed, paraffin-embedded human Pancreatic Carcinoma stained with Synaptophysin-Monospecific Mouse Monoclonal Antibody (SYP/3551).

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SDS-PAGE Analysis Purified Synaptophysin Mouse Monoclonal Antibody (SYP/3551). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Synaptophysin-Monospecific Mouse Monoclonal Antibody (SYP/3551).

Product Details

Synonyms

Major synaptic vesicle protein p38; MRX96; MRXSYP; Syn p38; Syp; SYPH

Positive Control

HepG2, SH-SY-5Y, HeLa or Y79 cells. Pancreas, Cerebellum or Pheochromocytoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 224-313) of human Synaptophysin (SYP) protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Dog

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

38kDa

Specificity & Comments

This Monospecific monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wiedenmann B, et al. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell. 1985; 41:1017-28.

Bioinformatics

  •  Entrez Gene ID: 6855
  •  Gene Symbol: MSH2
  •  SwissProt: IDP08247
  •  Chromosome Location: Xp11.23
  •  Unigene: 632804
NBT03551