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Home >> Antibodies >> RET Proto-oncogene

RET Proto-oncogene

Mouse Monoclonal Antibody [Clone RET/2795]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with RET Mouse Monoclonal Antibody (RET/2795).

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Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with RET Mouse Monoclonal Antibody (RET/2795).

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Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with RET Mouse Monoclonal Antibody (RET/2795).

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Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with RET Mouse Monoclonal Antibody (RET/2795).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using RET Mouse Monoclonal Antibody (RET/2795).

Product Details

Synonyms

Cadherin family member 12 (CDHF12); Cadherin related family member 16 (CDHR16); ELKS; HSCR1; Hydroxyaryl protein kinase; MEN2A; MEN2B; MTC1; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor ret; PTC; RET; RET ELE1; RET51; RET9

Positive Control

Breast, Prostate or Colon Carcinoma.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic, Cell Surface and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

150kDa (precursor); 170kDa (Mature)

Specificity & Comments

The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Airaksinen, M.S. et al. (1999) Mol Cell Neurosci 13, 313-25.

Bioinformatics

  •  Entrez Gene ID: 5979
  •  Gene Symbol: RET
  •  SwissProt: P07949
  •  Chromosome Location: 10q11.21
  •  Unigene: 350321
NBT02795