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Home >> Antibodies >> Protocadherin FAT2 (FAT Atypical Cadherin 2)

Protocadherin FAT2 (FAT Atypical Cadherin 2)

Mouse Monoclonal Antibody [Clone 8C5]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Protocadherin FAT2 Monoclonal Antibody (8C5).

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Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Protocadherin FAT2 Monoclonal Antibody (8C5).

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SDS-PAGE Analysis Purified Protocadherin FAT2 Monoclonal Antibody (8C5). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

FAT tumor suppressor homolog 2 (HFAT2); cadherin family member 8 (CDHF8); cadherin-related family member 9 (CDHR9); multiple EGF-like domains protein 1; multiple epidermal growth factor-like domains 1 (MEGF1); multiple epidermal growth factor-like domains protein 1; protocadherin FAT2.

Positive Control

Esophagus, Cervix, Uterus, Tonsil or Cerebellum.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Purified recombinant human FAT2 fusion protein.

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

480kDa

Specificity & Comments

Recognizes a protein of 480kDa, which is identified as FAT2. The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell-to-cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including -catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT2 (FAT tumor suppressor homolog 2) is a single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins. FAT2 contains one Laminin G-like domain, two EGF-like domains and 32 cadherin domains and is believed to function as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sano, K., et al. 1993. Protocadherins: a large family of cadherin-related molecules in central nervous system. EMBO J. 12: 2249-2256.
  2. Suzuki, S.T. 2000. Recent progress in protocadherin research. Exp. Cell Res. 261: 13-18.

Bioinformatics

  •  Entrez Gene ID: 2196
  •  Gene Symbol: FAT2
  •  SwissProt: Q9NYQ8
  •  Chromosome Location: 5q33.1
  •  Unigene: 591255
NBT01320