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Home >> Antibodies >> Natriuretic Peptide B / NPPB

Natriuretic Peptide B / NPPB

Mouse Monoclonal Antibody [Clone NPPB/4493]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human heart stained with Natriuretic Peptide BMouse Monoclonal Antibody (NPPB/4493). Inset: PBS instead of primary antibody; secondary only negative control.

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Formalin-fixed, paraffin-embedded human uterusstained with Natriuretic Peptide B Mouse Monoclonal Antibody (NPPB/4493). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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SDS-PAGE Analysis Purified NPM1 Mouse Monoclonal Antibody (NPPB/4493). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Natriuretic Peptide B Mouse Monoclonal Antibody (NPPB/4493).

Product Details

Synonyms

Brain natriuretic peptide 32; Brain type natriuretic peptide; Gamma brain natriuretic peptide; Natriuretic peptide B; Natriuretic peptide precursor B; natriuretic peptide, brain type; Natriuretic peptides B; natriuretic protein; NPPB

Positive Control

Human heart, liver or uterus.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human NPPB (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

25-36kDa (glycosylated BNP precursor); 12kDa (deglycosylated mature BNP)

Specificity & Comments

Natriuretic peptides comprise a family of three structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. These peptides possess potent natriuretic, diuretic and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. ANP, BNP and CNP are highly homologous within the 17-residue ring structure formed by an intramolecular disulfide linkage. The genes which encode for ANP and BNP map to human chromosome 1p36.22. The gene which encodes for CNP maps to human chromosome 2q37.1.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Mair, J., et al. 2001. The impact of cardiac natriuretic peptide determinationon the diagnosis and management of heart failure. Clin. Chem. Lab. Med.39: 571-588.

Bioinformatics

  •  Entrez Gene ID: 4879
  •  Gene Symbol: NPPB
  •  SwissProt: P16860
  •  Chromosome Location: 1p36.22
  •  Unigene: N/A