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Myoglobin (Muscle Cell Marker)

Mouse Monoclonal Antibody [Clone MB/2105]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

199.00

459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00

459.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded Rat Skeletal Muscle stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Formalin-fixed, paraffin-embedded Mouse Heart stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Formalin-fixed, paraffin-embedded Rat Skeletal Muscle stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Formalin-fixed, paraffin-embedded Mouse Heart stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Product Details

Synonyms

MB; Myoglobin; PVALB

Positive Control

SK-BR3 or T47D cells. Skeletal or Cardiac Muscle.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length Myoglobin (MB) protein.

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Mouse. Rat.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

17kDa

Specificity & Comments

Myoglobin is a cytosolic oxygen-binding protein responsible for the storage and diffusion of oxygen within myocytes. Expression of myoglobin is highest in skeletal and cardiac muscle. Myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia.In combination with other striated muscle markers such as vimentin and myogenin, myoglobin is helpful in the identification of rhabdomyosarcoma and tumors with skeletal muscle differentiation. Reportedly, myoglobin is expressed on epithelial cancer cells due to changed metabolic and environmental conditions.