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Myoglobin (Muscle Cell Marker) Antibody [MB/2105]

In Stock
Catalog Number Formulation Size Price
4151-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
4151-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
4151-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Myoglobin (Muscle Cell Marker) Antibody

Formalin-fixed, paraffin-embedded Rat Skeletal Muscle stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Myoglobin (Muscle Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded Mouse Heart stained with Myoglobin Mouse Monoclonal Antibody (MB/2105).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Myoglobin is a cytosolic oxygen-binding protein responsible for the storage and diffusion of oxygen within myocytes. Expression of myoglobin is highest in skeletal and cardiac muscle. Myoglobin is well accepted as an O2-storage protein in muscle, capable of releasing O2 during periods of hypoxia or anoxia.In combination with other striated muscle markers such as vimentin and myogenin, myoglobin is helpful in the identification of rhabdomyosarcoma and tumors with skeletal muscle differentiation. Reportedly, myoglobin is expressed on epithelial cancer cells due to changed metabolic and environmental conditions.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Dog, Human, Mouse, Rat
Research Areas
Cardiovascular, Hypoxia
Isotype / Light Chain
IgG2b / Kappa
Gene Name
MB
Positive Control
SK-BR3 or T47D cells. Skeletal or Cardiac Muscle.
Immunogen
Recombinant human full-length Myoglobin (MB) protein.
Alternate Names
Myoglobin, MB; Myoglobin; PVALB

Database Links

Entrez Gene ID
4151
SwissProt
P02144

Additional Information

Clone
MB/2105
Chromosome Location
22q12.3
Mol. Weight of Antigen
17kDa

Related Antibodies

View All MB Antibodies

Functions

  • Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Key References

  • Qiu, Y., et al. 1998. Identification of myoglobin in human smooth muscle. J. Biol. Chem. 273: 23426-23432.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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