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Home >> Antibodies >> MTAP (Tumor Suppressor Marker)

MTAP (Tumor Suppressor Marker)

Recombinant Mouse Monoclonal Antibody [Clone rMTAP/1813]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Kidney stained with MTAP Recombinant Mouse Monoclonal Antibody (rMTAP/1813).

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Formalin-fixed, paraffin-embedded human Kidney stained with MTAP Recombinant Mouse Monoclonal Antibody (rMTAP/1813).

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SDS-PAGE Analysis Purified MTAP Recombinant Mouse Monoclonal Antibody (rMTAP/1813). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

BDMF; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAPase; S-methyl-5''-thioadenosine phosphorylase

Positive Control

HepG2, A431, HeLa or MCF-7 cells. Human kidney tissues (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

31kDa

Specificity & Comments

Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nobori, T., et al. 1996. Proc. Natl. Acad. Sci. USA 93: 6203-6208.

Bioinformatics

  •  Entrez Gene ID: 4507
  •  Gene Symbol: MTAP
  •  SwissProt: Q13126
  •  Chromosome Location: 9p21.3
  •  Unigene: 193268
NBT03646