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Home >> Antibodies >> Monocyte Chemotactic Protein 2 (MCP2) / CCL8

Monocyte Chemotactic Protein 2 (MCP2) / CCL8

Mouse Monoclonal Antibody [Clone CCL8/3683]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
img

SDS-PAGE Analysis Purified MCP2 / CCL8 Mouse Monoclonal Antibody (CCL8/3683). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human adrenal gland stained with MCP2 / CCL8 Mouse Monoclonal Antibody (CCL8/3683). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

HC14; MCP2; MCP-2; SCYA8; SCYA10

Positive Control

Human small intestine, spleen or adrenal gland tissue.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Human recombinant MCP2 / CCL8 protein fragment (around aa1-99) (exact sequence is proprietary)

Cellular Localization

Secreted.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

11kDa

Specificity & Comments

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Barbai T, et al. Oncotarget. 2015 Oct 6;6(30):29111-28.

Bioinformatics

  •  Entrez Gene ID: 6355
  •  Gene Symbol: CCL8
  •  SwissProt: P80075
  •  Chromosome Location: 17q12
  •  Unigene: 271387