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  • HuProt™ Validated

Monocyte Chemotactic Protein 2 (MCP2) / CCL8 Antibody [CCL8/3312]

These antibodies are validated on HuProt™ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 6355-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6355-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6355-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6355-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Monocyte Chemotactic Protein 2 (MCP2) / CCL8 Antibody

SDS-PAGE Analysis of Purified MCP2 / CCL8 Mouse Monoclonal Antibody (CCL8/3312). Confirmation of Purity and Integrity of Antibody.

Monocyte Chemotactic Protein 2 (MCP2) / CCL8 Antibody - Image 2

Formalin-fixed, paraffin-embedded human adrenal gland stained with MCP2 / CCL8 Mouse Monoclonal Antibody (CCL8/3312).

Monocyte Chemotactic Protein 2 (MCP2) / CCL8 Antibody - Image 3

Formalin-fixed, paraffin-embedded human adrenal gland stained with MCP2 / CCL8 Mouse Monoclonal Antibody (CCL8/3312).

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
CCL8/3312
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Secreted
Gene Name
CCL8
Positive Control
Human small intestine, spleen or adrenal gland tissue.
Immunogen
Human recombinant MCP2 / CCL8 protein fragment (around aa24-98) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
Key References
  • Barbai T, et al. Oncotarget. 2015 Oct 6;6(30):29111-28.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6355
SwissProt
P80075
Chromosome Location
17q12
Mol. Weight of Antigen
11kDa
Alternate Names
C-C motif chemokine 8, HC14, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, Small-inducible cytokine A8, HC14; MCP2; MCP-2; SCYA8; SCYA10

Summary

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.

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