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Home >> Antibodies >> IDO2 / Indoleamine 2,3-dioxygenase 2

IDO2 / Indoleamine 2,3-dioxygenase 2

Mouse Monoclonal Antibody [Clone IDO2/2639]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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IHC analysis of formalin-fixed, paraffin-embedded human placenta. Staining using IDO2/2639 at 2ug/ml in PBS for 30min RT.HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using IDO2-Monospecific Mouse Monoclonal Antibody (IDO2/2639).

Product Details

Synonyms

3-dioxygenase 2; 3-dioxygenase-like protein 1; EC 1.13.11.; INDOL 1; Indoleamine 2; Indoleamine 2,3 dioxygenase 2; Indoleamine 2,3 dioxygenase like 1 protein; Indoleamine pyrrole 2,3 dioxygenase like 1; Indoleamine-pyrrole 2

Positive Control

Human placenta or liver.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 200-350) of human IDO2 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasm

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG, kappa

Mol. Weight of Antigen

47kDa

Specificity & Comments

IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Prendergast, GC et al. Cancer Res. 2017 Dec 15; 77(24): 6795 6811.

Bioinformatics

  •  Entrez Gene ID: 169355
  •  Gene Symbol: IDO2
  •  SwissProt: Q6ZQW0
  •  Chromosome Location: 8p11.21
  •  Unigene: 676257