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Home >> Antibodies >> HNF1A (Pancreatic Tumor Suppressor)

HNF1A (Pancreatic Tumor Suppressor)

Mouse Monoclonal Antibody [Clone HNF1A/2087]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).

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Formalin-fixed, paraffin-embedded human Pancreas stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).

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Formalin-fixed, paraffin-embedded human Small Intestine stained with HNF1A Mouse Monoclonal Antibody (HNF1A/2087).

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SDS-PAGE Analysis Purified HNF1A Mouse Monoclonal Antibody (HNF1A/2087). Confirmation of Integrity and Purity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using HNF1A Mouse Monoclonal Antibody (HNF1A/2087).

Product Details

Synonyms

Albumin proximal factor; Hepatic nuclear factor 1 alpha; Hepatic transcription factor 1 alpha; HNF-1A; Interferon production regulator factor; LFB1; LFB1 hepatic nuclear factor; Liver specific transcription factor LFB1; Maturity onset diabetes of the young 3 (MODY3); TCF1; Transcription factor 1 hepatic

Positive Control

Jurkat cells. Small Intestine or Pancreas.

Known Applications & Suggested Dilutions

ELISA, IHC-P         More Details

ELISA (For coating, order antibody without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 214-339) of human HNF1A protein (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

79kDa

Specificity & Comments

HNF1A belongs to the homeobox protein family and is an essential transcription factor for many hepatic genes involved in detoxification, homeostasis and metabolisms of glucose, lipid, steroid and amino acid. In addition, HNF1A is an important component of the transcriptional networks governing embryonic pancreas development and differentiation. as well as maintaining the growth and function of islet cells in adult. HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas. Recently, genome-wide association studies have implicatedHNF1Aas a susceptibility gene for pancreatic cancer.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bach, I., et al. 1993. EMBO J. 12: 4229-4242.

Bioinformatics

  •  Entrez Gene ID: 6927
  •  Gene Symbol: HNF1A
  •  SwissProt: P20823
  •  Chromosome Location: 12q24.31
  •  Unigene: 654455
NBT02087