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Home >> Antibodies >> GTF2IRD2

GTF2IRD2

Mouse Monoclonal Antibody [Clone PCRP-GTF2IRD2-1B4]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Flow cytometric analysis of PFA-fixed HeLa cells. GTF2IRD2 Mouse Monoclonal Antibody (PCRP-GTF2IRD2-1B4) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

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SDS-PAGE Analysis Purified GTF2IRD2 Mouse Monoclonal Antibody (PCRP-GTF2IRD2-1B4). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using GTF2IRD2 Mouse Monoclonal Antibody (PCRP-GTF2IRD2-1B4).

Product Details

Synonyms

FP630; GTF2IRD2A; GTF2IRD2 alpha

Positive Control

HeLa or K562 cells.

Known Applications & Suggested Dilutions

Flow Cyt, Western Blot         More Details

Flow Cytometry (1-2ug/million cells)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human GTF2IRD2 protein

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a

Mol. Weight of Antigen

107kDa

Specificity & Comments

The TFII-I family contains two highly homologous 949 amino acid proteins, GTF2IRD2 (GTF2I repeat domain containing 2) and GTF2IRD2B (general transcription factor II-I repeat domain-containing protein 2B). Localizing to the nucleus, these proteins are ubiquitously expressed and contain two GTF2I- like repeats. Encoded by a gene mapping to human chromosome 7q11.23, GTF2IRD2 and GTF2IRD2B are located in the Williams-Beuren syndrome (WBS) critical region. The deletion of genes located within this region results in WBS, possibly due to the unequal crossing over of highly homologous low-copy repeat sequences that flank the deleted region. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Tipney, H. J., et al. 2004. Eur. J. Hum Genet. 12: 551-560.
  2. Nucleic Acids Res. 38:D142-D148 (2010).

Bioinformatics

  •  Entrez Gene ID: 84163
  •  Gene Symbol: GTF2IRD2
  •  SwissProt: Q86UP8
  •  Chromosome Location: 7q11.23
  •  Unigene: 647039