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GTF2IRD2 Antibody [PCRP-GTF2IRD2-1B12]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
84163-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
84163-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
84163-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Western Blot (WB)
2-4ug/ml

Summary

The TFII-I family contains two highly homologous 949 amino acid proteins, GTF2IRD2 (GTF2I repeat domain containing 2) and GTF2IRD2B (general transcription factor II-I repeat domain-containing protein 2B). Localizing to the nucleus, these proteins are ubiquitously expressed and contain two GTF2I- like repeats. Encoded by a gene mapping to human chromosome 7q11.23, GTF2IRD2 and GTF2IRD2B are located in the Williams-Beuren syndrome (WBS) critical region. The deletion of genes located within this region results in WBS, possibly due to the unequal crossing over of highly homologous low-copy repeat sequences that flank the deleted region. WBS is an autosomal dominant genetic condition that is characterized by physical, cognitive and behavioral traits including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies and neurologic and musculoskeletal abnormalities.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or K562 cells.
Immunogen
Recombinant full-length human GTF2IRD2 protein
Alternate Names
General transcription factor II-I repeat domain-containing protein 2A, Transcription factor GTF2IRD2-alpha, FP630; GTF2IRD2A; GTF2IRD2 alpha

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-GTF2IRD2-1B12
Chromosome Location
7q11.23
Mol. Weight of Antigen
107kDa

Key References

  • Tipney, H. J., et al. 2004. Eur. J. Hum Genet. 12: 551-560.
  • Nucleic Acids Res. 38:D142-D148 (2010).

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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