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Home >> Antibodies >> Fodrin / Alpha Spectrin II (SPTAN1) / NEAS

Fodrin / Alpha Spectrin II (SPTAN1) / NEAS

Mouse Monoclonal Antibody [Clone SPTAN1/3352]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human lung stained with Fodrin Mouse Monoclonal Antibody (SPTAN1/3352).

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Formalin-fixed, paraffin-embedded human lung stained with Fodrin Mouse Monoclonal Antibody (SPTAN1/3352).

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SDS-PAGE Analysis Purified Fodrin Mouse Monoclonal Antibody (SPTAN1/3352). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Fodrin Mouse Monoclonal Antibody (SPTAN1/3352).

Product Details

Synonyms

Alpha-II spectrin; brain; EIEE5; Fodrin alpha chain; NEAS; Non erythrocytic spectrin alpha; non-erythroid alpha chain; SPECA; Spectrin alpha chain brain; Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spna2; SPTA2

Positive Control

Human colon or kidney tissues (IHC).

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment of human SPTAN1 protein (around aa 2351-2475) (exact sequence is proprietary))

Cellular Localization

Cytoplasm

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

240kDa

Specificity & Comments

Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Wang Yet al.Critical roles of aII spectrin in brain development and epileptic encephalopathy.J Clin Invest128:760-773 (2018).

Bioinformatics

  •  Entrez Gene ID: 6709
  •  Gene Symbol: SPTAN1
  •  SwissProt: Q13813
  •  Chromosome Location: 9q34.11
  •  Unigene: 372331