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Home >> Antibodies >> Fibroblast Activation Protein Alpha / FAP-1

Fibroblast Activation Protein Alpha / FAP-1

Mouse Monoclonal Antibody [Clone FAP/4854]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human placenta stained with Fibroblast Activation Protein Mouse Monoclonal Antibody (FAP/4854).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Fibroblast Activation Protein Mouse Monoclonal Antibody (FAP/4854).

Product Details

Synonyms

170 kDa melanoma membrane-bound gelatinase; DPPIV; FAP; FAPA; Fibroblast activation protein alpha; Integral membrane serine protease; Seprase

Positive Control

Human uterus, colon or pancreas. Fibroblast specific.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 1-200) of human FAP protein (exact sequence is proprietary)

Cellular Localization

Cell surface. Cell membrane.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

88kDa

Specificity & Comments

FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Scanlan, M. J., et al. (1994). Proceedings of the National Academy of Sciences of the United States of America, 91(12), 5657 5661.

Bioinformatics

  •  Entrez Gene ID: 2191
  •  Gene Symbol: FABP5
  •  SwissProt: Q12884
  •  Chromosome Location: 2q24.2
  •  Unigene: 654370