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Home >> Antibodies >> Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker)

Ferritin, Light Chain (Node-Negative Breast Tumor Prognostic Marker)

Mouse Monoclonal Antibody [Clone FTL/1389]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Western Blot Analysis of human HeLa cell lysate using Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1389).

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SDS-PAGE Analysis Purified Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1389). Confirmation of Integrity and Purity of Antibody

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Ferritin, Light Chain Mouse Monoclonal Antibody (FTL/1389)

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Western Blot Analysis of kidney tissue lysate using Ferritin, Light Chain Monoclonal Antibody (FTL/1389).

Product Details

Synonyms

Ferritin L chain; Ferritin L subunit; Ferritin light chain; Ferritin light polypeptide; FTL; LFTD; NBIA3

Positive Control

HepG2, HeLa, HL-60 or 293T cells. Pancreas, Liver, Kidney, Cerebellum or Testis.

Known Applications & Suggested Dilutions

ELISA, Western Blot         More Details

ELISA (For coating, order antibody without BSA)
Western Blot (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 38-165) of human FTL protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

19-25kDa

Specificity & Comments

Mammalian ferritins consist of 24 subunits made up of 2 types of polypeptide chains, ferritin heavy chain and ferritin light chain. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III). Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Y.Kaneko,T.Kitamoto,J.Tateishi,K.Yamaguchi. Ferritin immunohistochemistry as a marker for microglia. Acta Neuropathologica. 1989,Volume 79; 129-136
  2. Jezequel P, et. al. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study Int. J Cancer. 2012;131(2):426-37

Bioinformatics

  •  Entrez Gene ID: 2512
  •  Gene Symbol: FTL
  •  SwissProt: P02792
  •  Chromosome Location: 19q13.33
  •  Unigene: 433670
NBT01389