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Home >> Antibodies >> Drebrin 1 (DBN1)

Drebrin 1 (DBN1)

Mouse Monoclonal Antibody [Clone DBN1/2879]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Brain stained with Drebrin-1 Mouse Monoclonal Antibody (DBN1/2879).

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Formalin-fixed, paraffin-embedded human Cervix stained with Drebrin-1 Mouse Monoclonal Antibody (DBN1/2879).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Drebrin-1 Mouse Monoclonal Antibody (DBN1/2879).

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Western Blot Analysis of PC3 cell lysate using Drebrin-1 Mouse Monoclonal Antibody (DBN1/2879).

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SDS-PAGE Analysis Purified Drebrin-1 Mouse Monoclonal Antibody (DBN1/2879). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

Developmentally regulated brain protein; Drebrin 1; Drebrin; Drebrin E; Drebrin E2; Drebrin1; DrebrinE

Positive Control

PC3 cells. Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (aa 150-281) of human DBN1 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

120kDa

Specificity & Comments

Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2); and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer s disease and Down syndrome.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Shirao, T. 1995. The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. J. Biochem. 117: 231-236.

Bioinformatics

  •  Entrez Gene ID: 1627
  •  Gene Symbol: DBN1
  •  SwissProt: Q16643
  •  Chromosome Location: 5q35.3
  •  Unigene: 130316
NBT02879