SDS-PAGE Analysis Purified CD4 Mouse Monoclonal Antibody (RIV7). Confirmation of Purity and Integrity of Antibody.
Flow cytometry of lymphocyte gated PBMCs stained with CD4 monoclonal antibody (RIV7) (red) or isotype control (gray) followed by goat anti-mouse CF640R.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.