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Home >> Antibodies >> CD268 / BAFFR / TNFRSF13C

CD268 / BAFFR / TNFRSF13C

Mouse Monoclonal Antibody [Clone BAFFR/1557]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Tonsil stained with CD268 / BAFFR Mouse Monoclonal Antibody (BAFFR/1557).

img

SDS-PAGE Analysis Purified CD268 / BAFFR Mouse Monoclonal Antibody (BAFFR/1557). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

TNFRSF13C, BAFFR, BR3, BAFF receptor, BLyS receptor 3, CD268, CD268 antigen, CVID4, Prolixin, BAFF-R, BROMIX

Positive Control

Raji cells. Tonsil and lymph node.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CD268 protein

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

19kDa (Monomer); 40kDa (Dimer)

Specificity & Comments

Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

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200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Key References

  1. Thompson, J S, C Ambrose, et al. (2001) Science 293(5537): 2108-2111.
  2. G Fazio, G Cazzaniga, et al. (2017) BJH.

Bioinformatics

  •  Entrez Gene ID: 115650
  •  Gene Symbol: TNFRSF13C
  •  SwissProt: Q96RJ3
  •  Chromosome Location: 22q13.2
  •  Unigene: 344088
NBT01557