Formalin-fixed, paraffin-embedded human tonsil stained with CD268 / BAFFR Mouse Monoclonal Antibody (BAFFR/1558).

SDS-PAGE Analysis Purified CD268 / BAFFR Mouse Monoclonal Antibody (BAFFR/1558). Confirmation of Purity and Integrity of Antibody.

Printable Datasheet

CD268 / BAFFR / TNFRSF13C [BAFFR/1558]

Name: CD268 / BAFFR / TNFRSF13C
SKU: 115650-MSM2
Availability: InStock

Monoclonals Mouse Monoclonals Primary Antibodies

Summary

Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

Product Properties & Targets

Host

Mouse

Species Reactivity

Human

Isotype

IgG1

Cellular Localization

Membrane

Light Chain

kappa

Gene Name

TNFRSF13C

Positive Control

Raji cells. Tonsil and lymph node.

Immunogen

Recombinant full-length human CD268 protein

Alternate Names

Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, TNFRSF13C, BAFFR, BR3, BAFF receptor, BLyS receptor 3, CD268, CD268 antigen, CVID4, Prolixin, BAFF-R, BROMIX

Database Links

Entrez Gene ID

115650

Unigene

344088

SwissProt

Q96RJ3

Additional Information

Clone

BAFFR/1558

Human Gene Symbol

TNFRSF13C

Chromosome Location

22q13.2

Mol. Weight of Antigen

19kDa (Monomer); 40kDa (Dimer)

Functions

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Known Applications & Suggested Dilutions

Flow Cytometry (1-2ug/million cells)
,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

Thompson, J S, C Ambrose, et al. (2001) Science 293(5537): 2108-2111.
G Fazio, G Cazzaniga, et al. (2017) BJH.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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