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CD268 / BAFFR / TNFRSF13C Antibody [BAFFR/1558]

In Stock
Catalog Number Formulation Size Price
115650-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
115650-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
115650-MSM2-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
Raji cells. Tonsil and lymph node.
Immunogen
Recombinant full-length human CD268 protein
Alternate Names
Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BLyS receptor 3, TNFRSF13C, BAFFR, BR3, BAFF receptor, BLyS receptor 3, CD268, CD268 antigen, CVID4, Prolixin, BAFF-R, BROMIX

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
BAFFR/1558
Chromosome Location
22q13.2
Mol. Weight of Antigen
19kDa (Monomer); 40kDa (Dimer)

Functions

  • B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Key References

  • Thompson, J S, C Ambrose, et al. (2001) Science 293(5537): 2108-2111.
  • G Fazio, G Cazzaniga, et al. (2017) BJH.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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