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Home >> Antibodies >> CD195 (CC-Chemokine Receptor 5)

CD195 (CC-Chemokine Receptor 5)

Mouse Monoclonal Antibody [Clone 12D1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Formalin-fixed, paraffin-embedded human Stomach tissue stained with CD195 Mouse Monoclonal Antibody (12D1).

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SDS-PAGE Analysis of Purified CD195 Mouse Monoclonal Antibody (12D1). Confirmation of Purity and Integrity of Antibody

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Flow Cytometric Analysis of MCF-7 cells using CD195 Mouse Monoclonal Antibody (12D1); followed by goat anti-mouse IgG-CF488 (Blue); Isotype Control (Red).

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Flow Cytometric Analysis of U87 cells using CD195 Mouse Monoclonal Antibody (12D1); followed by goat anti-mouse IgG-CF488 (Blue); Isotype Control (Red).

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Immunofluorescence staining of PFA-fixed HeLa cells using CD195 Mouse Monoclonal Antibody (12D1) followed by goat anti-mouse IgG conjugated to CF488 (green).

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Flow Cytometric Analysis of PFA-fixed HeLa cells using CD195 Mouse Monoclonal Antibody (12D1) followed bygoat anti-mouse IgG-CF488 (Blue); Isotype Control (Red).

Product Details

Synonyms

CC Chemokine Receptor Type 5; CC-CKR-5; CCCKR5; CCR5; Chemokine CC motif receptor 5; Chemokine receptor CCR5; CHEMR13; CKR5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; MIP-1 alpha receptor

Positive Control

HeLa, U87 or MCF-7 cells. Human lymph node and tonsil.

Known Applications & Suggested Dilutions

IF, Flow Cyt, IHC-Fr         More Details

Immunofluorescence (1-2ug/ml)
Flow Cytometry (1-2ug/million cells)
Immunohistochemistry (Frozen) (1-2ug/ml for 30 minutes at RT)Optimal dilution for a specific application should be determined.

Immunogen

Human native CCR5 protein

Cellular Localization

Cell surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

45kDa

Specificity & Comments

Reacts with the N-terminal extracellular domain of CD195. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 transmembrane G protein-coupled receptor (GPCR). CCR5 regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands play an important role in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Together with the CD4 binding receptor, CCR5 plays a critical role in HIV entry into the target cells. Moreover, the CCR5 ligands macrophage inflammatory protein (MIP)-1 alpha, MIP-1 beta and RANTES act as endogenous inhibitors of HIV infection, making both CCR5 and its chemokine ligands attractive therapeutic targets for HIV infection. Recent studies have also highlighted the role of CCR5 in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Samson M, et al. 1996. Biochemistry 35:3362.2. Raport CJ, et al. 1996. J. Biol. Chem. 271:17161.3. Combadiere C, et al. 1996. J. Leukoc. Biol. 60:147.4. Deng H, et al. 1996. Nature 381:661.

Bioinformatics

  •  Entrez Gene ID: 1234
  •  Gene Symbol: CCR5
  •  SwissProt: P51681
  •  Chromosome Location: 3q21.31
  •  Unigene: 450802
NBT00156