Western Blot of HT20, A549, 293 and A431 cell lysates using C Catenin, gamma Mouse Monoclonal Antibody (11E4).
Confocal immunofluorescence image of HeLa cells using Catenin, gamma Mouse Monoclonal Antibody (11E4) Green (CF488) and Reddot is used to label the nuclei Red.
Western Blot Analysis of human HeLa and SKBR3 cell lysate using Catenin, gamma Mouse Monoclonal Antibody (11E4)
Flow Cytometric Analysis of PFA-fixed MCF cells. Catenin, gamma Mouse Monoclonal Antibody (11E4) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (, , and ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. T-catenin binds to E-catenin as well as to -catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for -T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.