Formalin-fixed, paraffin-embedded human Tonsil stained with Beta-Catenin Recombinant Rabbit Monoclonal Antibody (CTNNB1/2030R).
Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Beta-Catenin Recombinant Rabbit Monoclonal Antibody (CTNNB1/2030R).
Western Blot Analysis of HeLa cell lysate using Beta-Catenin Recombinant Rabbit Monoclonal Antibody (CTNNB1/2030R).
SDS-PAGE Analysis Purified Beta-Catenin Recombinant Rabbit Monoclonal Ab (CTNNB1/2030R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of PFA fixed HeLa cells using Beta-Catenin Recombinant Rabbit Monoclonal Ab (CTNNB1/2030R) followed by Goat anti-Rabbit IgG-CF488 (Blue); Isotype Control (Red).
Immunofluorescence Analysis of PFA fixed HeLa cells labeling Beta-Catenin with Beta-Catenin Recombinant Rabbit Monoclonal Ab (CTNNB1/2030R followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red)
Analysis of Protein Array containing more than 19,000 full-length human proteins using Catenin, beta (CTNNB1) Recombinant Rabbit Monoclonal Antibody (CTNNB1/2030R).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.