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Home >> Antibodies >> beta Amyloid

beta Amyloid

Mouse Monoclonal Antibody [Clone APP/3343]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Antibody (APP/3343). Confirmation of Purity and Integrity of SDS-PAGE Analysis Purified Beta Amyloid Mouse Monoclonal Antibody.

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Formalin-fixed, paraffin-embedded human brain stained with Beta Amyloid Mouse Monoclonal Antibody (APP/3343).

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Formalin-fixed, paraffin-embedded human brain stained with Beta Amyloid Mouse Monoclonal Antibody (APP/3343).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Beta Amyloid Mouse Monoclonal Antibody (APP/3343).

Product Details

Synonyms

CVAP; AAA; AICD-50; PN2; 50; Beta-APP42; AID; S-APP-alpha; 57; AD1; PN-II; Beta-APP40; 42; 40; APPI; Alzheimer disease amyloid protein; PreA4; ABETA; Amyloid intracellular domain 50; 57; 59 AICD-59; S-APP-beta; APP; AICD-57; ABPP; Protease nexin-II; Cerebral vascular amyloid peptide

Positive Control

Alzheimer's disease brain. Amyloidosis.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa578-680) of human Amyloid Beta protein (exact sequence is proprietary)

Cellular Localization

Membrane. Membrane > clathrin-coated pit. Cell surface protein that rapidly becomes internalized via clathrin-coated pits.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2b, kappa

Mol. Weight of Antigen

4-46kDa (β-Amyloid); 100-125kDa (Amyloid A4)

Specificity & Comments

Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the -Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Related Products



200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Key References

  1. Dukers DF, et al. J Clin Pathol 1999; 52:129 36.
  2. Kanavaros P, et al. Anticancer Res 1999; 19:1209 16.

Bioinformatics

  •  Entrez Gene ID: 351
  •  Gene Symbol: APP
  •  SwissProt: P05067
  •  Chromosome Location: 21q21.3
  •  Unigene: 434980