Formalin-fixed, paraffin-embedded human tonsil stained with BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R).
SDS-PAGE Analysis Purified BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of PFA-fixed K562 cells. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-Rabbit IgG-CF488 (blue); isotype control (red).
Immunofluorescence Analysis of PFA-fixed K562 cells labeling BCL10. BCL10 Recombinant Rabbit Monoclonal Antibody (BL10/2988R) followed by goat anti-rabbit IgG-CF488 (green). Phalloidin counterstain (red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF B activation in a NIK-dependent pathway. This MAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.