Formalin-fixed, paraffin-embedded human liver stained with Apolipoprotein A4 Mouse Monoclonal Antibody (APOA4/3372).
Formalin-fixed, paraffin-embedded human liver carcinoma stained with Apolipoprotein A4 Mouse Monoclonal Antibody (APOA4/3372).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Apolipoprotein A4 Mouse Monoclonal Antibody (APOA4/3372).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Apolipoproteins are protein components of plasma lipoproteins. The human apoA-I gene encodes a single chain, 243 amino acid protein which promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for the formation of most plasma cholesteryl esters. The human apoA-II gene encodes the second most abundant protein of HDL particles, where it influences plasma levels of free fatty acids (FFA). The human apoA-IV gene encodes a 396 amino acid preprotein, which after proteolytic processing is secreted from the intestine in association with chylomicron particles. ApoA-IV is a potent activator of LCAT in vitro. The human apoA-V gene encodes a 366 amino acid protein that is believed to be an important determinant of plasma triglyceride levels.