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Androgen Receptor (Marker of Androgen Dependence)

Mouse Monoclonal Antibody [Clone DHTR/882]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Mouse Monoclonal Antibody (DHTR/882).

Purified Androgen Receptor Mouse Monoclonal Antibody (DHTR/882). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor Mouse Monoclonal Antibody (DHTR/882).

Purified Androgen Receptor Mouse Monoclonal Antibody (DHTR/882). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

AIS; Dihydrotestosterone receptor (DHTR); HUMARA; HYSP1; Kennedy disease (KD); Nuclear receptor subfamily 3 group C member 4 (NR3C4); SMAX1; Spinal and bulbar muscular atrophy (SBMA); Testicular Feminization (TFM)

Positive Control

LNCap cells. Human testis, breast or prostate carcinoma.

Known Applications & Suggested Dilutions

Flow Cyt, IF, IHC-P More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Human DHTR recombinant protein fragment; aa151-350 (Exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human. Does not react with mouse.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

110kDa

Specificity & Comments

Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.