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Home >> Antibodies >> AIF1 / Iba1 (Microglia Marker)
AIF1 / Iba1 (Microglia Marker)

Mouse Monoclonal Antibody [Clone AIF1/1909]

Catalog #
Size
20 ug
100 ug
100 ug
Price (USD)
199.00
429.00
429.00
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Catalog No
Size
20 ug
100 ug
100 ug
Formulation
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Price (USD)
199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with AIF1 / Iba1 Mouse Monoclonal Antibody (AIF1/1909).

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SDS-PAGE Analysis Purified AIF1 / Iba1 Mouse Monoclonal Antibody (AIF1/1909). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded Human Lymph Node stained with AIF1 / Iba1 Mouse Monoclonal Antibody (AIF1/1909).

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Formalin-fixed, paraffin-embedded Human Kidney stained with AIF1 / Iba1 Mouse Monoclonal Antibody (AIF1/1909).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using AIF1 Mouse Monoclonal Antibody (AIF1/1909)

Product Details

Synonyms

Allograft inflammatory factor 1 (AIF1); balloon angioplasty responsive transcription (BART1); IBA1; Interferon responsive transcript 1; Ionized calcium-binding adapter molecule 1; IRT1; Microglia response factor (MRF1)

Positive Control

Lymph Node, Tonsil or Kidney

Known Applications & Suggested Dilutions

IHC-P         More Details
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Purified fragment of human recombinant AIF1 protein (around aa 1-146) (exact sequence is proprietary)

Cellular Localization

Cytoplasmic and Cell Surface

Species Reactivity

Human. Others not known.

Host / Ig Isotype

Mouse / IgG1, kappa

Specificity & Comments

AIF1 is a cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1, containing two EF domains, is induced by cytokines and Interferons. In an unstimulated state, AIF1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding AIF1 resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kelemen SE, Autieri MV. Expression of allograft inflammatory factor-1 in T lymphocytes. Am J Pathol2005; 167: 619-26.

Bioinformatics

  •  Entrez Gene ID: 199
  •  Gene Symbol: AIF1
  •  SwissProt: P55008
  •  Chromosome Location: 6p21.33
  •  Unigene: 76364
DOC#01909