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Home >> Antibodies >> 14-3-3E / Tryptophan 5-Monooxygenase

14-3-3E / Tryptophan 5-Monooxygenase

Mouse Monoclonal Antibody [Clone CPTC-YWHAE-1]

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Catalog No Formulation Size Price (USD)  
7531-MSM1-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
7531-MSM1-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 429.00
7531-MSM1-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 429.00
Human Entrez Gene ID 7531
Human SwissProt P62268
Human Unigene 513851
Human Gene Symbol YWHAE
Human Chromosome Location 17p13.3
Synonyms MDS; epididymis luminal protein 2; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; MSF L; protein kinase C inhibitor protein-1
Immunogen Recombinant human full-length YWHAE protein
Host / Ig Isotype Mouse / IgG2a, kappa
Mol. Weight of Antigen 29.4kDa
Cellular Localization Cytoplasm. Melanosome.
Species Reactivity Human. Others-not tested.

Specificity & Comments

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia.

Known Applications & Suggested Dilutions

Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.

Positive Control

HEK-293 or A-431 cell lines.

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Ikeda, Masashi, and Takao Hikita. OUP Academic, Oxford University Press, 24 July 2008
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