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Home >> Antibodies >> 14-3-3E / Tryptophan 5-Monooxygenase

14-3-3E / Tryptophan 5-Monooxygenase

Mouse Monoclonal Antibody [Clone CPTC-YWHAE-1]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Testis stained with 14-3-3E Mouse Monoclonal Antibody (CPTC-YWHAE-1).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using 14-3-3E Mouse Monoclonal Antibody (CPTC-YWHAE-1).

Product Details

Synonyms

MDS; epididymis luminal protein 2; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; MSF L; protein kinase C inhibitor protein-1

Positive Control

HEK-293 or A-431 cell lines.

Known Applications & Suggested Dilutions

WB         More Details

Western Blotting (0.5-1.0ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human full-length YWHAE protein

Cellular Localization

Cytoplasm. Melanosome.

Species Reactivity

Human. Others-not tested.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

29.4kDa

Specificity & Comments

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia.

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200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Ikeda, Masashi, and Takao Hikita. OUP Academic, Oxford University Press, 24 July 200

Bioinformatics

  •  Entrez Gene ID: 7531
  •  Gene Symbol: YWHAE
  •  SwissProt: P62268
  •  Chromosome Location: 17p13.3
  •  Unigene: 513851
DOC#02231