Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Recombinant Rabbit Monoclonal (TYRP1/2340R); DAB Chromogen.

Formalin-fixed, paraffin-embedded human Melanoma stained with TYRP1 Recombinant Rabbit Monoclonal (TYRP1/2340R); AEC Chromogen.

Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R).

SDS-PAGE Analysis Purified TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R). Confirmation of Purity and Integrity of Antibody.

Printable Datasheet

Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) [TYRP1/2340R]

Name: Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)
SKU: 7306-RBM8
Availability: InStock

Monoclonals Primary Antibodies Rabbit Monoclonals Recombinant Rabbit Monoclonals Recombinants

Summary

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Product Properties & Targets

Host

Rabbit

Species Reactivity

Human

Research Areas

Cardiovascular

Isotype

IgG

Cellular Localization

Melanosome, Melanosome membrane

Gene Name

TYRP1

Mol. Weight of Antigen

75kDa

Immunogen

Recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)

Database Links

Entrez Gene ID

7306

Unigene

270279

SwissProt

P17643

Additional Information

Clone

TYRP1/2340R

Human Gene Symbol

TYRP1

Chromosome Location

9p23

Known Applications & Suggested Dilutions

ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

Orlow, S.J., et al. 1994. High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex. J. Invest. Dermatol. 103: 196-201.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.