TSC22D1 Antibody [PCRP-TSC22D1-1A2]

These antibodies are validated on HuProtâ„¢ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 8848-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
8848-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8848-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8848-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • Flow
  • IF
  • WB

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Host
Mouse
Species Reactivity
Clone
PCRP-TSC22D1-1A2
Isotype
IgG1
Cellular Localization
Cytoplasm, Nucleus
Gene Name
Positive Control
HeLa or HepG2 cells.
Immunogen
Recombinant full-length human TSC22D1 protein
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Key References
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
13q14.11
Mol. Weight of Antigen
16kDa
Alternate Names
TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, Cerebral protein 2; Hucep2; KIAA1994; MGC17597; Regulatory protein TSC22; RP11 269C23.2; TGFB-stimulated clone 22 homolog; TGFB1I4; TGFbeta stimulated clone 22; Transcriptional regulator TSC 22; Transforming growth factor beta 1 induced transcript 4; Transforming growth factor beta 1 induced transcript 4 protein; TSC22D1

Summary

Transforming growth factor 尾-stimulated acts as a transcriptional regulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF尾 pathway and also the PPAR纬 signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

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