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TSC22D1 Antibody [PCRP-TSC22D1-1A2]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
8848-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
8848-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
8848-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml

Summary

Transforming growth factor 尾-stimulated acts as a transcriptional regulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF尾 pathway and also the PPAR纬 signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 /
Cellular Localization
Cytoplasm, Nucleus
Gene Name
Positive Control
HeLa or HepG2 cells.
Immunogen
Recombinant full-length human TSC22D1 protein
Alternate Names
TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, Cerebral protein 2; Hucep2; KIAA1994; MGC17597; Regulatory protein TSC22; RP11 269C23.2; TGFB-stimulated clone 22 homolog; TGFB1I4; TGFbeta stimulated clone 22; Transcriptional regulator TSC 22; Transforming growth factor beta 1 induced transcript 4; Transforming growth factor beta 1 induced transcript 4 protein; TSC22D1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-TSC22D1-1A2
Chromosome Location
13q14.11
Mol. Weight of Antigen
16kDa

Functions

  • Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.

Key References

  • Qin S, et al. Biochem Biophys Res Commun, 2018 Mar 18.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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