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TCF25 Antibody [PCRP-TCF25-1A11]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
22980-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
22980-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
22980-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Western Blot (WB)
2-4ug/ml

Summary

Nulp1 (nuclear localized protein 1), also known as TCF25 (transcription factor 25 (basic helix-loop-helix)), Hulp1 or FKSG26, is a 676 amino acid protein that plays a role in cell death. A member of the TCF25 family, Nulp1 utilizes its C-terminus to mediate transcriptional repression of SRF in vitro, and interacts with XIAP. Nulp1 localizes primarily to the nucleus but is also found in cytosol. Widely expressed, Nulp1 is found at high levels in embryonic brain and adult heart. The gene encoding Nulp1 maps to human chromosome 16q24.3, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn s disease, which is a gastrointestinal inflammatory condition.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or HepG2 cells.
Immunogen
Recombinant full-length human TCF25 protein
Alternate Names
Transcription factor 25, Nuclear localized protein 1, FKSG26; hKIAA1049; Hulp1; KIAA1049; Nuclear localized protein 1; NULP1; PRO2620; Transcription factor 25 (basic helix loop helix)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-TCF25-1A11
Chromosome Location
16q24.3
Mol. Weight of Antigen
77kDa

Functions

  • May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development.

Key References

  • Kang, K., et al. 2018. MicroRNA-326 inhibits melanoma progression by targeting KRAS and suppressing the AKT and ERK signalling pathways. Oncol. Rep. 39: 401-410.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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