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Formalin-fixed, paraffin-embedded human skeletal muscle stained with Sarcomeric Actinin Alpha 2 Mouse Monoclonal Antibody (ACTN2/3294).
Formalin-fixed, paraffin-embedded human skeletal muscle stained with Sarcomeric Actinin Alpha 2 Mouse Monoclonal Antibody (ACTN2/3294).
Formalin-fixed, paraffin-embedded human cardiac muscle stained with Sarcomeric Actinin Alpha 2 Mouse Monoclonal Antibody (ACTN2/3294).
SDS-PAGE Analysis Purified ACTN2 Mouse Monoclonal Antibody (ACTN2/3294). Confirmation of Purity and Integrity of Antibody.
Western Blot of human skeletal muscle tissue lysates using Sarcomeric Actinin Alpha 2 Mouse Monoclonal Antibody (ACTN2/3294).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Sarcomeric Actinin Alpha 2 Mouse Monoclonal Antibody (ACTN2/3294). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD�s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD�s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
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