PARTNERSHIP OPPORTUNITIES
Formalin-fixed, paraffin-embedded human spleen stained with Resistin Mouse Monoclonal Antibody (RETN/4326).
Formalin-fixed, paraffin-embedded human spleen stained with Resistin Mouse Monoclonal Antibody (RETN/4326).
Western Blot Analysis of human heart tissue lysate using Resistin Mouse Monoclonal Antibody (RETN/4326).
Formalin-fixed, paraffin-embedded human spleen stained with Resistin Mouse Monoclonal Antibody (RETN/4326).
Analysis of Protein Array containing more than 19,000 full-length human proteins using Resistin-Monospecific Mouse Monoclonal Antibody (RETN/4326). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
The cysteine-rich, adipose tissue-specific, secretory factor resistin (resistance to Insulin) also known as ADSF, is a secreted hormone that potentially links obesity to diabetes. Resistin is rich in serine and cysteine residues and contains a unique cysteine repeat motif. Resistin and the resistin-like molecules share the characteristic cysteine composition and other signature features. Resistin-like 伪 is a secreted protein that has restricted tissue distribution and is most highly expressed in adipose tissue. Another family member, resistinlike 尾, is a secreted protein expressed only in the gastrointestinal tract, particularly in the colon, in both mouse and human. Resistin-like 尾 expression is highest in proliferative epithelial cells and is markedly increased in tumors, suggesting a role in intestinal proliferation.
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