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Recombinant Prolactin Receptor (hPRL Receptor) Antibody [PRLR/3785R]

In Stock
Catalog Number Formulation Size Price
5618-RBM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
5618-RBM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
5618-RBM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Prolactin Receptor (hPRL Receptor) Antibody

SDS-PAGE Analysis of Purified Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R). Confirmation of Integrity and Purity of Antibody.

Recombinant Prolactin Receptor (hPRL Receptor) Antibody - Image 2

Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Prolactin Receptor Recombinant Rabbit Monoclonal (PRLR3785R).

Prolactin Receptor Antibody in Western Blot (WB)

Prolactin Receptor Antibody in Western Blot (WB)

Western blot analysis of Human Kidney tissue lysate using Prolactin Receptor Rabbit Recombinant Monoclonal Antibody (PRLR/3785R).

Prolactin Receptor Antibody in Western Blot (WB)

Prolactin Receptor Antibody in Western Blot (WB)

Western blot analysis of Kidney tissue lysates of different species using Prolactin Receptor Rabbit Recombinant Monoclonal Antibody (PRLR/3785R).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

Product Properties & Targets

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Cytokine Signaling
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Membrane, Secreted
Gene Name
PRLR
Positive Control
Testicular Carcinoma. Kidney
Immunogen
Recombinant full-length human PRLR protein
Alternate Names
Prolactin receptor, CPRLP, hPRL receptor, hPRLrI, Lactogen receptor, OPR, Pr-1, Pr-3, PRL-R, Prolactin receptor delta 7/11, RATPRLR, Secreted prolactin binding protein, Truncated testis-specific box 1-C prolactin receptor

Database Links

Entrez Gene ID
5618
SwissProt
P16471

Additional Information

Clone
PRLR/3785R
Chromosome Location
5p13.2
Mol. Weight of Antigen
70kDa

Related Antibodies

View All PRLR Antibodies

Functions

  • This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Key References

  • Breast Cancer Res. 2008;10(4):R68.
  • Histopathology. 2008;53(1):56-61

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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