NKX2.8 [NKX28/3233R]

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Summary

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Product Properties & Targets

Host
Species Reactivity
Isotype
IgG
Cellular Localization
Gene Name
NKX2-8
Mol. Weight of Antigen
26kDa
Immunogen
Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
NKX28/3233R
Human Gene Symbol
NKX2-8
Chromosome Location
14q13.3

Known Applications & Suggested Dilutions

  • ELISA (For coating, order Ab without BSA)
  • Optimal dilution for a specific application should be determined.

Key References

  • Regulation of alpha-fetoprotein expression by Nkx2.8. Kajiyama, Y., Tian, J., Locker, J. Mol. Cell. Biol. (2002)

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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