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Recombinant NKX2.8 Antibody [NKX28/3233R]

In Stock
Catalog Number Formulation Size Price
26257-RBM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
26257-RBM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
26257-RBM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus
Gene Name
Positive Control
Kidney or Thyroid tissue (IHC)., PC3 or MCF-7 cells. Human Liver
Immunogen
Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)
Alternate Names
Homeobox protein Nkx-2.8, Homeobox protein NK-2 homolog H, Homeobox protein NK-2 homolog H; NK2 homeobox 8; NK2 transcription factor related, locus 8; Nkx2 9; Nkx2-8; NKX2.8; NKX2G; NKX2H; OTTHUMP00000027959

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
NKX28/3233R
Chromosome Location
14q13.3
Mol. Weight of Antigen
26kDa

Key References

  • Regulation of alpha-fetoprotein expression by Nkx2.8. Kajiyama, Y., Tian, J., Locker, J. Mol. Cell. Biol. (2002)

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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