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MYCN Antibody [PCRP-MYCN-1A9]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4613-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4613-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4613-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells

Summary

The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleus.
Gene Name
Positive Control
293T whole cell lysates or recombinant Human n-Myc protein.
Immunogen
Recombinant protein domain (around aa335-463) of human MYCN protein
Alternate Names
N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, Class E basic helix-loop-helix protein 37 (bHLHe37); MODED; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; ODED; pp65/67; v myc (avian) myelocytomatosis viral related oncogene neuroblastoma derived

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-MYCN-1A9
Chromosome Location
2p24.3
Mol. Weight of Antigen
49.56 kDa

Functions

  • Positively regulates the transcription of MYCNOS in neuroblastoma cells.

Key References

  • Blackshaw S, et al. Nature methods15.5 (2018 May): 330-338.
  • Statement for PublicationAll investigators should include acknowledgment in the publications the benefit from the use of product. Suggested statement: PCRP-MYCN-1A9 was developed by JHU/CDI under Protein Capture Reagents Program of NICHD of the NIH.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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