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MEF2B (Transcriptional Activator) Antibody [PCRP-MEF2B-2F9]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
100271849-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
100271849-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
100271849-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml

Summary

The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members, termed MEF-2A, -2B, -2C, and -2D, arise from alternatively spliced transcripts. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. The MEF-2 family represents a second class of DNA binding regulatory proteins. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2a /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or Ramos cells.
Immunogen
Recombinant full-length human MEF2B protein
Alternate Names
Myocyte-specific enhancer factor 2B, RSRFR2, Serum response factor-like protein 2, MADS box transcription enhancer factor 2; MDS1 EVI1; Mef2b; Myocyte enhancer factor 2B; Myocyte-specific enhancer factor 2B; PRDM3; RSRFR2; Serum response factor like protein 2; XMEF2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-MEF2B-2F9
Chromosome Location
19p13.11
Mol. Weight of Antigen
160kDa

Functions

  • Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Key References

  • Hidaka, K., et al. 1995. The MEF2B homologue differentially expressed inmouse embryonal carcinoma cells. Biochem. Biophys. Res. Commun. 213:555-560.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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