Liver X Receptor beta (LXRB) (Orphan Receptor) Antibody [LXRB/2731]

These antibodies are validated on HuProtâ„¢ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 7376-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
7376-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7376-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7376-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • ELISA

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Host
Mouse
Applications
Species Reactivity
Clone
LXRB/2731
Isotype
IgG2c
Light Chain
Kappa
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa, SW480 or A549 cells. Liver.
Immunogen
Recombinant full-length human NR1H2 (LXRB) protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Key References
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
19q13.33
Mol. Weight of Antigen
56kDa
Alternate Names
Oxysterols receptor LXR-beta, Liver X receptor beta, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Ubiquitously-expressed nuclear receptor, Liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR beta; LXRB; NER1; Nuclear orphan receptor LXR beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2 (NR1H2); OR-1; Oxysterols receptor LXR-beta; RIP15; Steroid hormone nuclear receptor NER; Ubiquitously-expressed nuclear receptor (UNR)

Summary

The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.

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