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L-Myc / MYCL1 (Transcription Factor) Antibody [PCRP-MYCL-2D5]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4610-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4610-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4610-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml
Western Blot (WB)
2-4ug/ml

Summary

Oncogene-encoded proteins c-Myc, N-Myc, and L-Myc function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors, the N-Myc gene in neuroblastomas, and the L-Myc gene in human small cell lung carcinomas. c-Myc protein is a transcription factor localized to the nucleus of the cell. It seems to be involved in activating the transcription of growth-related genes. c-Myc binds to DNA during transcription as a heterodimeric complex with Max. c-Myc is phosphorylated in vitro by p44/42 MAP kinase at Ser62 and in vivo at both Thr58 and Ser62. Mutation of Thr58 and Ser62 to Ala inhibits the ability of c-Myc to activate transcription.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa cells. Human small cell lung carcinoma.
Immunogen
Recombinant full-length human MYCL protein
Alternate Names
Protein L-Myc, Class E basic helix-loop-helix protein 38, Protein L-Myc-1, V-myc myelocytomatosis viral oncogene homolog, bHLHe38; Class E basic helix-loop-helix protein 38; l myc 1 proto-oncogene; Myc related gene from lung cancer; oncogene lmyc; Protein L-Myc-1; v myc avian myelocytomatosis viral oncogene homolog 1 lung carcinoma derived

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-MYCL-2D5
Chromosome Location
1p34.2
Mol. Weight of Antigen
40.33kDa

Key References

  • Blackshaw S, et al. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature methods 15.5 (2018 May): 330-338.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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