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IGFBP3 Antibody [IGFBP3/3517]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
3486-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3486-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3486-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Human placenta or lymph node.
Immunogen
Recombinant human full-lengthIGFBP3protein
Alternate Names
Insulin-like growth factor-binding protein 3, Acid stable subunit of the 140 K IGF complex; Binding protein 29; Binding protein 53; BP53; Growth hormone dependent binding protein; IBP3; IGF binding protein 3; IGFBP3; Insulin-like growth factor binding protein 3 precursor

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IGFBP3/3517
Chromosome Location
7p12.3
Mol. Weight of Antigen
40/44kDa

Functions

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275).

Key References

  • Vassilieva, I., et al. 2020. Paracrine senescence of human endometrial mesenchymal stem cells: a role for the Insulin-like growth factor binding protein 3. Aging 12: 1987-2004.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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