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Recombinant IgE Immunoglobulin Antibody [rIGHE/13128]

In Stock
Catalog Number Formulation Size Price
3497-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
3497-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
3497-MSM4-P1ABX
Purified Ab without BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin epsilon (IgE) exists as a monomer. The IgE heavy chain is an e chain, and the light chains are either k- or l- chains. IgE is significantly involved in the allergic response of the body. It binds to receptors on the surface of basophils, mast cells and activated eosinophils. One dominant functional activity of IgE is the sensitization of mast cells. IgE binds to the Fc e RI receptor on the surface of mast cells, causing the cell to release chemicals that induce reactions such as sneezing and coughing. IgE also helps to protect the host against large parasites. It coats the surface of the parasite attracting eosinophils via the Fc e RI receptor. The eosinophils can then attack the parasites that are too large to be ingested by phagocytes.

Product Properties & Targets

Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
Immunogen
Recombinant human IGHE protein
Alternate Names
Immunoglobulin heavy constant epsilon, Igh2 antibody; IGHE antibody; IGHEP1 antibody; Immunoglobulin heavy constant epsilon antibody, constant region of heavy chain of IgE immunoglobulin epsilon

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
rIGHE/13128
Chromosome Location
14p13

Key References

  • Leoh LS, Daniels-Wells TR, Penichet ML
  • Pellizzari G, Bax HJ, Josephs DH, et al

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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