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FAT1 (FAT atypical cadherin 1) Antibody [FAT1-3D7/1]

In Stock
Catalog Number Formulation Size Price
2195-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2195-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2195-MSM1-P1BX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunofluorescence (IF)
1-2ug/ml
Western Blot (WB)
2-4ug/ml

Summary

The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgM / Kappa
Cellular Localization
Cell membrane, Nucleus
Gene Name
Positive Control
Wild type imaginal discs from third instar Drosophila larvae.
Immunogen
Cytoplasmic domain of Drosophila Fat protein.
Alternate Names
Protocadherin Fat 1, Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog, Cadherin family member 7 precursor (CDHF7); Cadherin ME5; Cadherin related tumor suppressor homolog precursor (FAT protein homolog); FAT tumor suppressor homolog 1; hFat 1; Homolog of Drosophila tumor suppressor FAT precursor; nuclear form; Protein fat homolog; Protocadherin Fat 1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
FAT1-3D7/1
Chromosome Location
4q35.2
Mol. Weight of Antigen
500kDa

Functions

  • Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.

Key References

  • Maddox, J. and Arnold, N.W. 1980. Prevention of industrial accidents. Med. J. Aust. 2: 484.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified by Protein L. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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