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ENAH / MENA (Actin Regulator) Antibody [ENAH/1988]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
55740-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
55740-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
55740-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Western Blot (WB)
2-4ug/ml

Summary

The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. WASP is a downstream effector of Cdc42 and has been implicated in actin polymerization and cyto- skeletal organization. Distantly related proteins, VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), are involved in the regulation of cytoskeletal dynamics. Both Mena and VASP accumulate at focal adhesions. Mena is highly expressed in the developing nervous system and may be involved in growth cone motility and axon guidance.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2c / Kappa
Cellular Localization
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Filopodium, Focal adhesion, Lamellipodium, Synapse
Gene Name
Positive Control
MCF-7 cells. Uterus.
Immunogen
Recombinant fragment of human MENA protein (around aa 485-589) (exact sequence is proprietary)
Alternate Names
Protein enabled homolog, ENA; ENAH; MENA; NDPP1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
ENAH/1988
Chromosome Location
Unavailable
Mol. Weight of Antigen
80/88/140kDa

Functions

  • Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity).

Key References

  • Stewart, D.M., et al. 1996. J. Clin. Invest. 97: 2627-2634.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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