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CTBP2 (C-terminal binding protein 2) Antibody [PCRP-CTBP2-2D11]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
1488-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1488-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1488-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

The gene CTBP2 (C-terminal binding protein 2) encodes a member of the CtBP-family. The gene is mapped to human chromosome 21q21.3. It is found to be expressed ubiquitously, with higher expression in the heart, skeletal muscle, and pancreas. The gene CTBP2 (C-terminal binding protein 2) encodes a protein that functions as a transcriptional co-repressor of several tumor suppressor genes resulting in enhanced cancer cell migration and invasion. Its expression is found to be upregulated in hepatocellular carcinoma (HCC). It may be a potential prognostic marker for post liver resection HCC. It is involved in several types of tumor initiation, progression and response to therapy. It is found to interact with the C-terminal region of adenovirus type 2/5 E1A protein, a region that negatively regulates tumorigenicity and the extent of oncogenic transformation.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Cell junction, Nucleus, Synapse
Gene Name
Positive Control
Molt-4 or HeLa cells.
Immunogen
Recombinant full-length human CTBP2 protein
Alternate Names
C-terminal-binding protein 2, C-terminal-binding protein 2 (CTBP2); Ribeye

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-CTBP2-2D11
Chromosome Location
21q21.3
Mol. Weight of Antigen
95.2kDa

Functions

  • Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
  • Isoform 2 probably acts as a scaffold for specialized synapses.

Key References

  • Xin Zheng et. al. Oncotarget, 2015 Feb 28;6(6):3752-69.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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