CD282 (Toll-Like Receptor 2) [TLR2/3894R]

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Summary

This MAb reacts with human Toll-like receptor 2 (TLR2). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Product Properties & Targets

Host
Species Reactivity
Isotype
IgG
Gene Name
TLR2
Mol. Weight of Antigen
~90kDa
Immunogen
Recombinant full-length human TLR2 protein

Database Links

Entrez Gene ID
Unigene
SwissProt

Additional Information

Clone
TLR2/3894R
Human Gene Symbol
TLR2
Chromosome Location
4q32

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA,Optimal dilution for a specific application should be determined.

Key References

  • Lien E, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem. 1999 Nov 19;274(47):33419-25.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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