SDS-PAGE Analysis Purified CD257 Mouse Monoclonal Antibody (C257/1638). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis Purified CD257 Mouse Monoclonal Antibody (C257/1638). Confirmation of Purity and Integrity of Antibody.

Printable Datasheet

CD257 / BAFF / TNFSF13B [C257/1638]

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Summary

BAFF/CD257 is a type II transmembrane protein, and a member of the tumor necrosis factor ligand superfamily. It is proteolytically cleaved to form a soluble protein. BAFF, like other TNF ligand family members, forms homo-trimers. The predicted molecular weight of a BAFF monomer is approximately 31kDa. It is expressed on peripheral blood B and T lymphocytes, monocytes, macrophages, and dendritic cells and is upregulated by IFN- BAFF prevents apoptosis and promotes B cell survival by binding the BAFF-specific receptor (BAFFR/BR3).

Product Properties & Targets

Host
Mouse
Applications
ELISA
Species Reactivity
Human
Isotype
IgG1
Cellular Localization
Cell membrane, Secreted
Light Chain
Kappa
Gene Name
TNFSF13B
Positive Control
Jurkat cells. Tonsil and lymph node.
Immunogen
Purified recombinant human CD257 protein
Alternate Names
Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, ApoL related ligand TALL 1; B lymphocyte stimulator; B-cell-activating factor; BAFF; BLyS; CD257; Dendritic cell-derived TNF-like molecule; DTL; PRO738; TALL-1; THANK; TNFSF13B; TNFSF20; Tumor necrosis factor ligand superfamily member 13b; Tumor necrosis factor ligand superfamily member 20; ZTNF4

Database Links

Entrez Gene ID
10673
Unigene
525157
SwissProt
Q9Y275

Additional Information

Clone
C257/1638
Human Gene Symbol
TNFSF13B
Chromosome Location
13q32-q34
Mol. Weight of Antigen
31kDa (Monomer)

Functions

  • Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
  • Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
  • Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Known Applications & Suggested Dilutions

  • ELISA (For coating, order Ab without BSA)
  • Optimal dilution for a specific application should be determined.

Key References

  • Schneider P, et al. 1999. J. Exp. Med. 189:1747.
  • Moore PA, et al. 1999. Science 285:260.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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