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CD137 / 4-1BB / TNFRSF9 Antibody [4-1BB/3201]

In Stock
Catalog Number Formulation Size Price
3604-MSM1-B1
Purified Ab conjugated to Biotin
0.5ml at 100ug/ml
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 /
Cellular Localization
Cell surface, Membrane
Gene Name
Positive Control
Human kidney cancer
Immunogen
A recombinant fragment (around aa 19-188) of human CD137 protein (exact sequence is proprietary)
Alternate Names
Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, 4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of mouse 4 1BB; induced by lymphocyte activation (ILA); Interleukin activated receptor homolog of mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
4-1BB/3201
Chromosome Location
1p36.23
Mol. Weight of Antigen
32kDa (monomer); 85kDa (dimer)

Functions

  • Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Key References

  • Zhao S, et al. CD137 ligand is expressed in primary and secondary lymphoid follicles and in B-cell lymphomas: diagnostic and therapeutic implications. Am J Surg Pathol. 2013 Feb;37(2):250-8.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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