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MPO Antibodies

Myeloperoxidase (MPO) has a molecular weight of approximately 150 kDa. This enzyme is primarily expressed in cells of the myeloid lineage, including neutrophils and monocytes, and is a key component of azurophilic granules in these cells. It is an enzyme that catalyzes the formation of hypochlorous acid (HOCl) from hydrogen peroxide (H2O2) and chloride ions, contributing to the oxidative burst during the immune response, thus playing a crucial role in the innate immune system.

MPO is associated with inflammatory and autoimmune diseases. Elevated levels of Myeloperoxidase are observed in conditions such as vasculitis, rheumatoid arthritis, and inflammatory bowel disease. Additionally, it is implicated in the pathogenesis of atherosclerosis, contributing to oxidative stress and endothelial dysfunction.

Antibodies against MPO are used in research to detect and quantify levels in biological samples. Immunohistochemistry, ELISA, and other immunoassays employing anti-MPO antibodies help researchers study the role of MPO in various diseases. It is used as a biomarker in clinical settings to assess inflammation and diagnose certain diseases. For example, high levels of Myeloperoxidase in blood or tissue samples may indicate an inflammatory or autoimmune condition.

Synonyms

Myeloperoxidase | Myeloperoxidase | 89 kDa myeloperoxidase | 84 kDa myeloperoxidase | Myeloperoxidase light chain | Myeloperoxidase heavy chain, 84 kDa / 89 kDa myeloperoxidase; EC 1.11.1.7; EC1.11.2.2; fj80f04; MPO; mpx; myeloid-specific peroxidase; Myeloperoxidase; Myeloperoxidase heavy chain; Myeloperoxidase light chain

Research Areas

Cardiovascular, Immunology, Hematopoietic Stem Cells

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MPO

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