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Home >> Antibodies >> VEGFR2 / CD309 / Flk-1 / KDR3 (Hemangioblast Marker)

VEGFR2 / CD309 / Flk-1 / KDR3 (Hemangioblast Marker)

Mouse Monoclonal Antibody [Clone KDR721]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00

Product Details

Synonyms

CD309; Fetal liver kinase 1 (FLK-1); KDR; Kinase insert domain receptor (a type III receptor tyrosine kinase); KRD1; Ly73; Protein tyrosine kinase receptor FLK1; Protein-tyrosine kinase receptor flk-1; Vascular endothelial growth factor receptor 2

Positive Control

HUVEC cells. Human lymph nodes and tonsils.

Known Applications & Suggested Dilutions

Flow Cyt, IF, Func.         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Functional Studies (Order Ab without BSA & Azide)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human VEGF-R2 protein

Cellular Localization

Cell Surface

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

150-230kDa

Specificity & Comments

CD309, also known as VEGFR2, KDR3, and Flk-1 (Mouse), is a type I transmembrane glycoprotein. It is a member of the CSF-1/PDGF receptor family of type III tyrosine kinase receptors. Human VEGFR2 is mainly expressed by endothelial cells, embryonic tissues, and megakaryocytes. It plays an important role in the regulation of angiogenesis, vasculogenesis, and vascular permeability. The ligands of VEGFR2 include VEGF-A, VEGF-C, VEGF-D, and VEGF splice isoforms. Ligation of VEGFR2 with its ligands results in the receptor dimerization and auto-phosphorylation, stimulating endothelial cell proliferation and migration.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Murohara T, et al. 1998. Circulation. 97:99.
  2. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley Sons Inc, Publication.
  3. Ferrara N and Gerber HP. 2002. Acta.Haematol. 106:148.

Bioinformatics

  •  Entrez Gene ID: 3791
  •  Gene Symbol: KDR
  •  SwissProt: P35968
  •  Chromosome Location: 4q12
  •  Unigene: 479756
NBT00721